概述
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货号
KDD72501
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检测方法
Colorimetric -
样本类型
Plasma, Serum -
实验类型
Quantitative -
检测范围
0.31-5 μg/mL -
灵敏度
0.156 μg/ml -
精准度
CV<20%
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回收率
80-120% -
运输
2-8 ℃ -
稳定性和存储
The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition. -
别名
CSL-362-AML, CSL362, JNJ-56022473, CAS: 1826831-79-1
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背景
Talacotuzumab (TAL, JNJ-56022473) is an IgG1 monoclonal antibody targeting CD123 preferentially via antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells and has been shown to induce potent in vitro ADCC against IL3RA-expressing AML blasts/LSC and to reduce leukemic cell growth in murine xenograft models of human AML. In addition, the antibody inhibits signaling by IL-3, the main ligand of CD123, to reduce the proliferation of leukemic progenitor cells.
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