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货号
YHA41901
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描述
NPC1/Niemann-Pick C1 protein (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
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表达系统
E. coli -
种属
Homo sapiens (Human) -
蛋白长度
Gln23-Asp266 -
预测分子量
29.31 kDa -
性质
Recombinant -
内毒素水平
Please contact with the lab for this information. -
纯度
>90% as determined by SDS-PAGE. -
Accession号
O15118 -
应用
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress -
状态
Lyophilized -
保存溶液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. -
重悬
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. -
运输
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. -
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. -
别名
NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1, receptor for ebolavirus, receptor for ebolavirus
