Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction
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Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures
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Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein
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TarIKGC: A Target Identification Tool Using Semantics-Enhanced Knowledge Graph Completion with Application to CDK2 Inhibitor Discovery
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A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses
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A multi-antigen vaccinia vaccine broadly protected mice against SARS-CoV-2 and influenza A virus while also targeting SARS-CoV-1 and MERS-CoV
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Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles
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A Peptide-Copper Self-Assembled Nanoparticle for Enhanced Cuproptosis by Metabolic Reprogramming in Tumor Cells
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Identification of TIGAR, a direct proteomic target associated with the hypoglycemic effect of Berberine
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Discovery of Balasubramide Derivative with Tissue-Specific Anti-Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1
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Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: a joint view of experiments and simulations
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Preclinical pharmacology characterization of HX009, a novel PD1 x CD47 Bi-specific antibody
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Microglia-derived Galectin-9 drives amyloid-β pathology in Alzheimer's disease
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Immunogenicity and Efficacy of Combined mRNA Vaccine Against Influenza and SARS-CoV-2 in Mice Animal Models
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Protocol for isolating antigen-specific monoclonal antibodies from immunized mice utilizing the Beacon platform
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S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury
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Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α in developing livers, an effect alleviated by ascorbic acid
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Improving combination cancer immunotherapy by manipulating dual immunomodulatory signals with enzyme-triggered, cell-penetrating peptide-mediated biomodulators
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The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2
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Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker
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