过敏性疾病在工业化国家已成为重要的公共卫生问题,影响全球四分之一以上的人群。过敏反应通常源于机体免疫系统针对特定抗原(如反复接触相同物质)而产生的IgE抗体,导致病理性过度反应,并伴随组织炎症、损伤及功能障碍。在严重情况下,可能出现呼吸困难或过敏性休克,需要及时治疗。
Fig 1.IgE介导的FcεRI激活导致过敏的分子机制
为了推动过敏原相关的分子机制研究和治疗创新,AntibodySystem 本月推出了多重过敏原靶点的精选抗原和抗体产品,涵盖了包括自然界过敏原、食物类过敏原和人工合成过敏原等在内的常见致敏源。产品如尘螨排泄物的 Der f 1、花粉中的 Phl p 1 和 Phl p 5,以及牛奶中的 Bos d 5 和 Bos d 11 等靶点,为科研人员提供高效的解决方案,帮助他们在环境过敏研究、花粉症诊断、食物过敏筛查等多方面展开深入研究。这些精选产品不仅支持过敏性疾病的基础研究,还为临床治疗方案的开发与验证提供了有力工具。
■尘螨过敏原 Der f 1/DERF1
靶点:Der f 1, Der p 1
描述:尘螨的主要致敏蛋白,常见于家庭环境中。易诱发呼吸道过敏疾病,如哮喘和鼻炎。
应用场景:用于环境过敏研究和过敏疾病的开发。
Catalog No:YXX51701 |
Name:Recombinant European house dust mite Der p 1/DERP1 Protein, N-His |
Accession:P08176 |
Protein length:Arg19-Leu320 |
Applications:ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
Expression system:E. coli |
Detects Dermatophagoides farinae DERF1/DERP1 Antibody (4C1) in indirect ELISAs. |
■花生致敏蛋白 Ara h 2
靶点:Ara h 1, Ara h 2
描述:花生中的主要致敏蛋白,易导致严重的食物过敏反应,甚至出现过敏性休克。
应用场景:食物过敏筛查及过敏性休克的防护。
Catalog No:YZZ03701 |
Name:Recombinant Peanut Ara h 2/Conglutin-7 Protein, N-Trx-His |
Accession:Q6PSU2 |
Protein length:Ala21-Tyr172 |
Applications:ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
Expression system:E. coli |
SDS PAGE for Recombinant Arachis hypogaea (Peanut) Ara h 2/Conglutin-7 protein |
■IgE/IGHE
靶点:IgE, IGHE
描述:IgE(免疫球蛋白E)是参与速发型过敏反应的关键抗体,能够与特定抗原结合并激活肥大细胞和嗜碱性粒细胞,引发组织炎症反应。与IgE相关的异常反应常见于哮喘、过敏性鼻炎等疾病。
应用场景:用于过敏性疾病研究及IgE介导的过敏反应监测,也适用于开发抗IgE治疗策略,如单克隆抗体治疗哮喘和慢性荨麻疹等疾病。
Catalog No:RHJ92702 |
Name:Anti-Human IgE/IGHE Antibody (SAA0342) |
Accession:P01854 |
Isotype:IgG1, kappa |
Applications:ELISA, FCM |
Host species:Mouse |
Flow-cytometry using anti-human IgE antibody.IgE Transfected CHO cells |
随着过敏性疾病的日益普遍,过敏原的检测和靶向治疗变得尤为重要。AntibodySystem 提供的精选抗原和抗体,帮助科研人员从多层次揭示过敏反应的本质,并支持临床治疗方案的开发与验证。这些高质量产品为个性化医疗研究、诊断工具优化和食品安全保障奠定了坚实基础。
访问 AntibodySystem 官网过敏原相关专题,了解更多关于过敏原检测解决方案的信息,并获取最新科研工具,让您的研究更上一层楼。
更多热门相关也可见以下产品清单:
货号 |
品名 |
---|---|
EBK33501 |
Recombinant Bovine LGB/Beta-lactoglobulin Protein, C-His |
EWK27301 |
Recombinant Honeybee Hyaluronidase/Hya Protein, C-His |
EXX24001 |
Recombinant Aspergillus fumigatus Asp f 22/enoA Protein, N-His |
EXX51601 |
Recombinant American house dust mite Der f 1/DERF1 Protein, C-His |
EXX51602 |
Recombinant American house dust mite Der f 1 Protein, N-His |
EXX51603 |
Recombinant American house dust mite Der f 1 Protein, C-His |
EXX53201 |
Recombinant Blomia tropicalis (Mite) Blo t 1 Protein, C-His |
EZZ05601 |
Recombinant Wheat Tri a 28/IAA1 Protein, C-His |
EZZ05701 |
Recombinant Wheat Tri a 30 Protein, C-His |
YBC01401 |
Recombinant Bovine Bos d 6/ALB Protein, N-His |
YBC18101 |
Recombinant Bovine Bos d 11/CSN2 Protein, N-His |
YBK33501 |
Recombinant Bovine Bos d 5/LGB Protein, N-His |
YCK15101 |
Recombinant Gallus gallus Gal d 2/OVA/Ovalbumin Protein, N-His |
YCK81001 |
Recombinant Chicken Gal d 4/LYZ Protein, N-His |
YCK84201 |
Recombinant Gallus gallus Allergen Gal d I Protein, N-His |
YCK84202 |
Recombinant Chicken Allergen Gal d I Protein, N-His |
YFK29901 |
Recombinant Cat Fel d 1A/CH1 Protein, N-GST & C-His |
YFK30001 |
Recombinant Cat Fel d 1B/CH2 Protein, N-GST & C-His |
YHB98101 |
Recombinant Human Hom s 5/KRT6A Protein, N-His |
YQK33601 |
Recombinant Dog Can f 1/Allergen Dog 1 Protein, N-His |
YWD39901 |
Recombinant Common carp Cyp c 1/PVALB Protein, N-His |
YWK33301 |
Recombinant German cockroach Bla g 1/Allergen Bla g I Protein, N-His |
YWK33401 |
Recombinant German cockroach Bla g 2/Allergen Bla g II Protein, N-His |
YWK53001 |
Recombinant Penaeus monodon Pen m 1/TM1/Tropomyosin Protein, N-His |
YWK53002 |
Recombinant Giant tiger prawn Pen m 1/TM1 Protein, C-His |
YWK81001 |
Recombinant Horse Equ a 6/LYZ Protein, N-Trx-His & C-His |
YWK84001 |
Recombinant Greasyback shrimp Met e 1/Tropomyosin Protein, N-His |
YWK84101 |
Recombinant Brown shrimp Allergen Pen a 1 Protein, N-His |
YWN55401 |
Recombinant Honeybee Api m 11/MRJP1 Protein, N-His-SUMO |
YWN55501 |
Recombinant Honeybee Api m 4/Melittin Protein, N-His-SUMO |
YXX08601 |
Recombinant Pityrosporum furfur Mal f 1/Allergen Pit o 1/Mala s 1 Protein, N-His |
YXX08701 |
Recombinant Aspergillus fumigatus Asp f 1/mitF Protein, N-His |
YXX12301 |
Recombinant Alternaria rot fungus Alt a 1/ALTA1 Protein, N-His |
YXX12401 |
Recombinant Aspergillus fumigatus Asp f 15 Protein, N-His |
YXX50201 |
Recombinant Mite Blo t 5/BLOT5 Protein, N-His |
YXX51501 |
Recombinant European house dust mite DERP7/Der p 7 Protein, N-His |
YXX51701 |
Recombinant European house dust mite Der p 1/DERP1 Protein, N-His |
YXX51801 |
Recombinant European house dust mite Der p 2/DERP2 Protein, N-His |
YXX53101 |
Recombinant European house dust mite Der p 23 Protein, N-GST & C-His |
YXX53201 |
Recombinant Mite Blo t 1.0101 Protein, N-His |
YXX53301 |
Recombinant European house dust mite Der p 10/Tropomyosin Protein, N-His |
YXX54301 |
Recombinant Yellowfever mosquito Aed a 2/AeD7L1 Protein, C-His |
YXX54401 |
Recombinant Yellowfever mosquito Aed a 4/MAL1 Protein, N-His |
YZZ01901 |
Recombinant Common timothy PHLPII/Phl p 2 Protein, N-His |
YZZ02001 |
Recombinant European white birch Bet v 1/Allergen Bet v I-A Protein, N-His |